ManchesterUnited have made a brilliant start to the 2017-18 season following five victories and one stalemate in their opening six fixtures, while the Red Devils have scored 17 times and conceded twice.
And speaking at his weekly news conference at Carrington on Friday, Mourinhosaid: "It's not an injury that I can have the hope I have with [Antonio] Valencia or [Phil] Jones".
"Long term injuries I don't speak about them - Ibra [Zlatan Ibrahimovic], Pogba and [Marcos] Rojo".
Pogba was originally expected to miss a little more than a month with the injury.
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There was hope Pogba's injury wouldn't be as severe as first thought.
United are said to have consulted with Sakari Orava, the renowned Finnish surgeon who recently operated on Barcelona's record signing Ousmane Dembele, to determine whether or not he might need to go under the knife.
"What I am saying is that from all the injuries we have, I hope we can have some players available Saturday". The opposition is not the problem.
"We played Wednesday night and we arrived in Manchester at 4am, so home at 5am, and we have to play tomorrow, so mentality is very important".
United have won each of their four games without the former Juventus man, including a 4-0 win against Everton, as well as thumping CSKA Moscow 4-1 in midweek.
Midfielder Ruben Loftus-Cheek and defender James Tomkins will also be missing today.