However, a 2-minute spell shortly after the interval was all it took for CSKA's dreams of a spot in the last 16 to evaporate, as goals from Romelu Lukaku and Marcus Rashford eventually saw the Premier League giants emerge with all 3 points.
The 24-year-old will miss matches against Bournemouth and West Brom, as well as the Manchester derby against local rivals Man City, which is to be played this coming Sunday.
There is no doubt Jose Mourinho's side will go into Saturdays game brimming with confidence after two impressive away wins in a week against Watford and Arsenal, although the loss of their creative spark in midfield Paul Pogba is a major blow.
"So now David is the third best".
Unsurprisingly, ever since then, he's found first-team football hard to come by and has even been left out of matchday squads by Mauricio Pochettino.
Mourinho added: "It's the truth".
But, according to a lesser known UEFA ruling, Daley Blind, who had slid off the pitch in the build up to the goal, was playing Dzagoev onside. Romero. Because he plays [against CSKA] and my goalkeeper is always the best goalkeeper in the world.
"But I think it doesn't matter the team we get in the draw".
"We picked up some good experience from this Champions League campaign, especially for the young players".
He has only used him on occasions when the result was clearly a foregone conclusion, and even ahead of a game where United just need to avoid losing by five - something that hasn't happened since 2011 - you can sense an element of reluctance to use him in his tone.