City recovered to win that game 5-3 but lost the tie. Even Raheem Sterling, who has been transformed by Guardiola, will know he cannot afford any complacency after being left out of the team for the first leg of the Champions League semifinal at Anfield.
The pair have contributed to Liverpool's 33 goals in the Champions League this term that set another record for the most scored in the competition by an English side in a single campaign.
City's European exit capped a wretched week, which also saw them blow the chance to clinch the Premier League title on Saturday when Manchester United came from two goals down to beat their bitter rivals.
The slender scoreline belied City's dominance but they were denied what seemed a legitimate second three minutes before half-time when Sane bundled in from close range, Milner's intervention when Karius punched clear rendering the German onside. Should they lose at St. Mary's to afford Mark Hughes his first Premier League points as Saints manager, will Conte be able to cling on for the trip to Wembley?
Speaking to BT Sport after the match, the City manager spoke witheringly of Mateu Lahoz's officiating. The likes of Shakhtar Donetsk's Fred, Nice's Jean-Michel Seri, Monaco's Thomas Lemar and Chelsea's Eden Hazard all on the talented manager's radar.
"City took all the risks they could take, we needed a bit of luck and a disciplined defending formation".
"What we didn't get last Wednesday".
Liverpool also didn't escape, with UEFA listing charges of "setting off of fireworks" and "throwing of objects".
"From a personal point of view I don't want Real Madrid in the semi-finals". Almost exactly a year later, they must show they can build on the victory at City to offer hope of a closer title race next season. They have a relatively favourable run-in, with every opponent aside from Leicester currently in the bottom half. I was not overly happy at half-time to be honest.